abstract：:The liver is an immunologically unique organ, consisting of resident hematopoietic and parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also becoming increasingly clear that tumor-induced immunosuppression occurs via many of the same cellular mechanisms which contribute to the ...

journal_title：International immunopharmacology

authors： Chan T,Wiltrout RH,Weiss JM

更新日期：2011-07-01 00:00:00

abstract：:3, 5,7-trihydroxy-4'-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT) is a novel derivative of Icariin (ICA), the major active ingredient of Herba Epimedii, a herb used in traditional Chinese and alternative medicine. We previously demonstrated its anti-inflammatory effect in murine innate immune cells and activated ...

journal_title：International immunopharmacology

authors： Zhou J,Wu J,Chen X,Fortenbery N,Eksioglu E,Kodumudi KN,Pk EB,Dong J,Djeu JY,Wei S

更新日期：2011-07-01 00:00:00

abstract：:Tumor growth occurs by the imbalance between cells with effector function and cells with suppressor/regulatory functions. To investigate this scenario we administered the chemical carcinogen Urethane in BALB/c mice and followed these animals during 120 days to observe lung tumor development. In another set of experime...

journal_title：International immunopharmacology

authors： Rosin FC,Pedregosa JF,de Almeida JS,Bueno V

更新日期：2011-07-01 00:00:00

abstract：:Cigarette smoking is highly associated with increased cardiovascular disease complications. The female population, however, manifests reduced cardiovascular morbidity. We define nicotine's effect upon human umbilical vein endothelial cells (HUVECs), determine whether estradiol might ameliorate endothelial dysfunction ...

journal_title：International immunopharmacology

authors： Wang LL,Zhao JL,Lau WB,Zhang YQ,Qiao ZD,Wang YJ

更新日期：2011-06-01 00:00:00

abstract：:Bone destruction associated with rheumatoid arthritis (RA) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. Studies on the immune regulation of osteoclasts in RA have promoted the new research field of "ost...

journal_title：International immunopharmacology

authors： Okamoto K,Takayanagi H

更新日期：2011-05-01 00:00:00

abstract：:Regulatory T (Treg) cells play an important role in the pathogenesis of inflammatory bowel disease (IBD). In the present study, we found that a superagonistic CD28-specific monoclonal antibody (supCD28mAb, D665) could preferentially stimulate expansion of CD4+Foxp3+ Treg cells. Foxp3(EGFP) mice were orally administrat...

journal_title：International immunopharmacology

authors： Chen J,Xie L,Toyama S,Hünig T,Takahara S,Li XK,Zhong L

更新日期：2011-05-01 00:00:00

abstract：:This study investigated the efficacy of cord blood-derived cytokine-induced killer (CB-CIK) biotherapy combined with second-line chemotherapy in treating advanced solid malignancies after first-line chemotherapy failure. Forty patients with advanced solid malignancies after first-line chemotherapy failure were divided...

journal_title：International immunopharmacology

authors： Niu Q,Wang W,Li Y,Qin S,Wang Y,Wan G,Guan J,Zhu W

更新日期：2011-04-01 00:00:00

abstract：:Isothiocyanates can inhibit nuclear factor-kappaB (NF-kappaB) activation. Interleukin (IL)-1β activates the NF-kappaB, which in turn activates proteins involved in inflammation. IL-1β is directly associated with caspase-1 activation. We tested the anti-inflammatory effect of allyl isothiocyanate (AITC) in mast cells. ...

journal_title：International immunopharmacology

authors： Han NR,Park W,Um JY,Kim HM,Jeong HJ

更新日期：2011-04-01 00:00:00

abstract：:Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax app...

journal_title：International immunopharmacology

authors： Yadav VR,Prasad S,Sung B,Aggarwal BB

更新日期：2011-03-01 00:00:00

abstract：:Although numerous studies demonstrate the participation of nitric oxide (NO) in various inflammatory diseases, the precise function of NO in allergic asthma remains unclear. We investigated whether iNOS inhibition could interfere with the kinetics of VLA-4 and Mac-1 expression and adhesion properties of bone marrow an...

journal_title：International immunopharmacology

authors： Pelaquini EH,Guimarães Lde A,Benetti LR,Fernandes LG,Tamashiro WM,Conran N,Ferreira HH

更新日期：2011-02-01 00:00:00

abstract：:Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent ma...

journal_title：International immunopharmacology

authors： Tanaka S,Koizumi S,Masuko K,Makiuchi N,Aoyagi Y,Quivy E,Mitamura R,Kano T,Ohkuri T,Wakita D,Chamoto K,Kitamura H,Nishimura T

更新日期：2011-02-01 00:00:00

abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...

journal_title：International immunopharmacology

authors： Cao W,Zhang W,Liu J,Wang Y,Peng X,Lu D,Qi R,Wang Y,Wang H

更新日期：2011-02-01 00:00:00

abstract：:High-mobility group protein 1 (HMGB1) has been identified as a late-acting mediator of inflammation. The receptor for advanced glycation end products (RAGE) is the main receptor and mediates the cytokine activity of HMGB1. Since HMGB1 also exhibits heparin-binding activity, we investigated whether heparin interferes w...

journal_title：International immunopharmacology

authors： Ling Y,Yang ZY,Yin T,Li L,Yuan WW,Wu HS,Wang CY

更新日期：2011-02-01 00:00:00

abstract：:Paclitaxel has become one of the most effective and widely used chemotherapeutic agents over the past decades. Although it has shown promise to selectively deplete regulatory T (Treg) cells in our previous study, the underlying molecular mechanism remains to be further elucidated. The present study focused on the effe...

journal_title：International immunopharmacology

authors： Liu N,Zheng Y,Zhu Y,Xiong S,Chu Y

更新日期：2011-02-01 00:00:00

abstract：:Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic a...

journal_title：International immunopharmacology

authors： Yuk JE,Lee MY,Kwon OK,Cai XF,Jang HY,Oh SR,Lee HK,Ahn KS

更新日期：2011-02-01 00:00:00

abstract：:Cartilage degradation is one of the pathological changes of osteoarthritis (OA), and accumulating evidence suggests an excess of matrix metalloproteinases (MMPs) plays a role in this cartilage breakdown. Here, we investigated the effects of chlorogenic acid (CGA) on the mRNA and protein expression of MMPs in interleuk...

journal_title：International immunopharmacology

authors： Chen WP,Tang JL,Bao JP,Hu PF,Shi ZL,Wu LD

更新日期：2011-01-01 00:00:00

abstract：:Chelidonic acid (CA) is known as an inhibitor of the rat brain glutamate decarboxylase. However, the pharmacological effects of CA in allergic reactions have not yet been defined. Here, we show the effects and the mechanism of CA in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model. CA significantly decrease...

journal_title：International immunopharmacology

authors： Oh HA,Kim HM,Jeong HJ

更新日期：2011-01-01 00:00:00

abstract：:The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investi...

journal_title：International immunopharmacology

authors： Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

更新日期：2010-12-01 00:00:00

abstract：:Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections. Now, extensive research in the field of neutro...

journal_title：International immunopharmacology

authors： Kumar V,Sharma A

更新日期：2010-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder in which lymphocytic infiltration mediated mainly by pro-inflammatory cytokines. In this study, we examined the effect of combined exercise training on the levels of IFN-γ, IL-4 and IL-17 in the plasma and the supernatant of peripheral blood lymp...

journal_title：International immunopharmacology

authors： Golzari Z,Shabkhiz F,Soudi S,Kordi MR,Hashemi SM

更新日期：2010-11-01 00:00:00

abstract：:Recently, a guanosine analog, 7-allyl-7,8-dihydro-8-oxo-guanosine (loxoribine), has been identified as a selective Toll-like receptor (TLR)7 agonist. Bearing in mind the controversy regarding the expression of TLR7 by human myeloid dendritic cells (DCs) and its significance for functions of these cells, the goal of th...

journal_title：International immunopharmacology

authors： Dzopalic T,Dragicevic A,Vasilijic S,Vucevic D,Majstorovic I,Bozic B,Balint B,Colic M

更新日期：2010-11-01 00:00:00

abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

journal_title：International immunopharmacology

authors： Inoue K,Koike E,Takano H

更新日期：2010-11-01 00:00:00

abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...

journal_title：International immunopharmacology

authors： Oliveira RA,Azevedo-Ximenes E,Luzzati R,Garcia RC

更新日期：2010-11-01 00:00:00

abstract：:Stephanoside E (STE) and its aglycone Stephanthraniline A (STA) isolated from the stems of Stephanotis mucronata (Blanco) Merr. were evaluated for their suppressive potentials on Th1 and Th2 immune responses in vitro, and the effects of the C-3 sugar chains on their activities were discussed. STE and STA significantly...

journal_title：International immunopharmacology

authors： Chen F,Ni Y,Ye Y,Sun H,Li X,Xu S

更新日期：2010-10-01 00:00:00

abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

journal_title：International immunopharmacology

authors： Clement F,Venkatesh YP

更新日期：2010-10-01 00:00:00

abstract：:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. ...

journal_title：International immunopharmacology

authors： Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

更新日期：2010-10-01 00:00:00

abstract：:Propolis is considered to down-regulate type I allergy, but the effective components of propolis remain unknown. In addition, propolis components vary depending on the area from which they are collected due to variations among wild plants in an area. Therefore, we compared the effects of water and ethanol extracts of ...

journal_title：International immunopharmacology

authors： Nakamura R,Nakamura R,Watanabe K,Oka K,Ohta S,Mishima S,Teshima R

更新日期：2010-09-01 00:00:00

abstract：:We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

journal_title：International immunopharmacology

authors： Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

更新日期：2010-09-01 00:00:00

abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

journal_title：International immunopharmacology

authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with sepsis, trauma, and shock. ...

journal_title：International immunopharmacology

authors： Feng X,Zhang F,Dong R,Wang H,Liu J,Liu X,Li W,Yao J,Xu J,Yu B

更新日期：2010-08-01 00:00:00

abstract：:Dietary ingredients can decrease the risk of a variety of human cancers. Quercetin (3,3',4',5,7-pentahydroxyflavone) has a long history of consumption as part of the normal human diet and is able to induce growth inhibition in multiple cancer cells. In an attempt to generate more potent therapeutic effect for breast c...

journal_title：International immunopharmacology

authors： Du G,Lin H,Yang Y,Zhang S,Wu X,Wang M,Ji L,Lu L,Yu L,Han G

更新日期：2010-07-01 00:00:00

abstract：:Lung innate immune response plays an important role in the clearance of pathogens from lungs, however, profound activation of innate immune cells (alveolar macrophages or neutrophils) can lead to development of acute lung inflammation or injury by producing various pro-inflammatory molecules (IL-1, TNF-alpha and H2O2 ...

journal_title：International immunopharmacology

authors： Kumar V,Harjai K,Chhibber S

更新日期：2010-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stim...

journal_title：International immunopharmacology

authors： Lee YS,Choi EM

更新日期：2010-07-01 00:00:00

abstract：:We studied the suitability of our murine model for the treatment trials of atopic dermatitis (AD). In this model topical application of ovalbumin (OVA) together with bacterial superantigen, staphylococcal enterotoxin B (SEB) induces a cutaneous disease resembling AD. Injured mouse skin was treated with three different...

journal_title：International immunopharmacology

authors： Lehto M,Savinko T,Wolff H,Kvist PH,Kemp K,Lauerma A,Alenius H

更新日期：2010-04-01 00:00:00

abstract：:The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory...

journal_title：International immunopharmacology

authors： Ribeiro A,Ferraz-de-Paula V,Pinheiro ML,Sakai M,Costa-Pinto FA,Palermo-Neto J

更新日期：2010-04-01 00:00:00

abstract：:Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and n...

journal_title：International immunopharmacology

authors： Nam KN,Choi YS,Jung HJ,Park GH,Park JM,Moon SK,Cho KH,Kang C,Kang I,Oh MS,Lee EH

更新日期：2010-04-01 00:00:00

abstract：:Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 sup...

journal_title：International immunopharmacology

authors： Lv M,Qiao C,Lin Z,Yu M,Hou C,Sun Y,Li Y,Feng J,Shen B

更新日期：2010-02-01 00:00:00

abstract：:Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune response against bacterial infection or their products. Thus, regulation of innate immune response plays a critical role in controlling exaggerated systemic inflammation responsible for sepsis development. However, treatment of ...

journal_title：International immunopharmacology

authors： Kumar V,Sharma A

更新日期：2010-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

journal_title：International immunopharmacology

authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

更新日期：2010-01-01 00:00:00

abstract：:To be effective, vaccines against the highly variable HIV-1 must elicit antibodies to a huge number of clinical isolates. For this purpose, new strategies to overcome this variability are needed. We previously reported a useful immunogenic strategy which consists of conjugating multiple antigen peptides (MAPs) to HBsA...

journal_title：International immunopharmacology

authors： Cruz LJ,Cabrales A,Iglesias E,Aguilar JC,González LJ,Reyes O

更新日期：2009-11-01 00:00:00